朱薛辰 博士 助理教授 副研究员

个人履历：

2008-2012      四川大学  学士

2012-2017      清华大学  博士

2017-2019      清华大学  博士后

2019-2023      西湖大学  博士后

2023-至今  北京大学 基础医学院 助理教授/副研究员

研究方向和兴趣：

1. 胚胎发育：卵母细胞成熟、胚层分化、体轴形成、神经诱导、器官分化

2. 先天缺陷：基因筛选和先天缺陷病理学

承担基金项目：

1.  朱薛辰人才专项 新体制教研系列人员启动经费   300万

2.《分泌蛋白 c14orf93 在脊椎动物胚胎前后极性建立中的功能研究》 国家自然科学基金面上项目 项目负责人   2024年1月-2027年12月    50万

3.《胚胎中细胞代谢规律与细胞命运决定的关联机制》 国家重点研发计划 “发育编程及其代谢调节”专项 课题骨干     2023年12月-2028年11月   154万元/2200万

4.《卵母细胞成熟障碍的致病机制研究》 北京大学临床 +X 青年专项 课题负责人   2024年5月-2024年12月    15.5万/25.5万

5.《胚胎发育及器官形成的新基因新机制与早筛体系研究》 北京市自然科学基金 重点研究专题项目 课题负责人   2024年7月-2028年6月    57万 /300万

代表论文：

1.Huaxiang Zhao*, Qing He*, Xiantao Wu, Xuain Liang, Yuhuan Jiao, Yue Zhang, Shanying Bao,LinpingXu, Yuxia Hou#,Xuechen Zhu#, Yi Ding#, Identification of rare loss-of-function variants in FAM3Bassociated with non-syndromic orofacial clefts. Genomics.2023May:115(3):1 10630.

2.Zhu X*, Huang G*, Zeng C*, Zhan X*, Liang K*, Zhao Y, Wang P, Wang Q , Zhou Q, Tao Q, Liu MLei J, Yan C, Shi Y. Near-atomic Structure of the Cytoplasmic Ring of the Xenopus laevis Nuclear Pore Complex.Science.2022 Jun 10:376(6598):eab18280(*co-frst author)

3.Huang G*, Zhan X*, Zeng C*, Zhu X*, Liang K*, Zhao Y, Wang P, Wang Q , Zhou Q, Tao Q, Liu MLei J, Yan C, Shi Y. Cryo-EM Structure of the nuclear ring ftom Xenopus laevis nuclear pore complex.Cell Research.2022 Apr,32(4):349-358(*c-o-frst author)

4.Huang G*, Zhan X*, Zeng C*, Liang K*, Zhu X*, Zhao Y, Wang P, Wang Q, Zhou Q, Tao Q, Liu MLei J, Yan C, Shi y, Cryo-EM stricture of the Inner Ring from Xenopus laevis Nuclear Pore Complex.Cell Research,2022 Mar,32(5):451-460.(* co-frst author)

5.Zhu X*, Wang p*, Wei J, Li Y, Zhai J, Zheng T, Tao Q. Lysosomal degradation of the maternal dorsal determinant Hwa safeguards dorsal body axis formation, EMBO Reports. 2021 Dec 6:22(12):e53185.

6.Zhang F*, Zhu X*, Wang P*, He Q, Huang H, Zheng T, Li Y, Jia H, Xu L, Zhao H, Colozza G, Tao Q.De Robertis EM, Ding Y. The cytokine FAM3B/PANDER is an FGFR ligand that promotes posterior development in Xenopus. Proc Natl Acad Sci USA. 2021 May 18;118(20):e2100342118.

7.Huang G*, Zhang y*, Zhu X*, Zeng C*, Wang Q, Zhou Q, Tao Q, Liu M, Lei J, Yan C, Shi Y. Structureof the cytoplasmic ring of the Xenopus laevis nuclear pore complex by crvo-electron microscopy single particle analysis.Cell Research. 2020 Jun;30(6):520-531.

8.Zhang Y*, Li S*, Zeng C*, Huang G*, Zhu X*, Wang Q, Wang K, Zhou Q, Yan C, Zhang W, Yang G.Liu M, Tao O, Lei J. Shi y. Molecular architecture of the luminal ring of the Xenopus laevis nuclear porecomplex.Cell Research.2020 Jun;30(6):532-540.

9.Yan L*, Chen j*, Zhu X*, Sun J, Wu X, Shen W, Zhang W, Tao Q, Meng A. Maternal Hulwa dictates the embryonic body axis through B-catenin in vertebrates. Science. 2018 Nov 23:362(6417).

10. Lin H*, Zhu X*, Chen G, Song L, Gao L, Khand AA, Chen Y, Lin G, Tao Q. KDM3A-mediated demethylation of histone H3 lysine 9 facilitates the chromatin binding of Neurog2 during neurogenesis.Development.2017 0ct 15:144(20):3674-3685.

11. Zhu X, Xing R, Tan R, Dai R, Tao O. The RNF146 E3 ubiquitin ligase is required for the control of Wnt signaling and body pattern formation in Xenopus, Mechanisms of Development. 2017 Oct; 147.28-36.

12. Gao L*, Zhu X*, Chen G, Ma X, Zhang Y, Khand AA, Shi H, Gu F, Lin H, Chen Y, Zhang H, He L, TaoO. A novel role for Ascll in the regulation of mesendoderm formation via HDAC-dependent antagonismof VegT.Development.2016 Feb 1;143(3):492-503.

13. Zhu X, Min Z, Tan R, Tao Q. NF2/Merlin is required for the axial pattern formation in the Xenopus laevisembryo.Mechanisms of Development 138 Pt 3,305-3 12.

14. Wu QJ*, Zhu X*, Xiao X, Wang P, Xiong da K, Gong CY, Wang Ys, Yang L, Wei YQ. A novel vaccine delivery system: biodegradable nanoparticles in thermosensitive hydrogel. Growt Factors. 2011 Dec.29(6):290-7.